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Fish-eye disease
1 OMIM reference -
1 associated gene
8 connected diseases
8 signs/symptoms
Disease Type of connection
Familial LCAT deficiency
Apolipoprotein A-I deficiency
Familial renal amyloidosis due to Apolipoprotein AI variant
Primary systemic amyloidosis
Hyperlipidemia type 3
Lipoprotein glomerulopathy
Sea-blue histiocytosis
Familial renal amyloidosis due to Apolipoprotein AII variant
Synonym(s):
- FED
- Partial LCAT deficiency
Classification (Orphanet):
- Inborn errors of metabolism
- Rare endocrine disease
- Rare eye disease
- Rare genetic disease
- Rare renal disease
Classification (ICD10):
- Endocrine, nutritional and metabolic diseases -
Epidemiological data:
Class of prevalence: <1 / 1 000 000
Average age onset: adolescence / young
Average age of death: normal
Type of inheritance: autosomal recessive
External references:
1 OMIM reference -
1 MeSH reference: C538467
Gene symbol UniProt reference OMIM reference
LCAT P04180606967
Very frequent
- Autosomal recessive inheritance
- Corneal clouding / opacity / vascularisation
- Hyperlipidemia / hypercholesterolemia / hypertriglyceridemia

Occasional
- Angor pectoris / myocardial infarction
- Arterial atheroma / precocious atherosclerosis / arteriosclerosis
- Hepatomegaly / liver enlargement (excluding storage disease)
- Lymphadenopathy / polyadenopathies
- Splenomegaly